Regeneration of ischemic tissue and improvement of blood supply using stem cells − up-todate knowledge and potential use in no-option critical limb ischemia

Abstract

Introduction: Cardiovascular disorders and their complications are the leading causes of death all over the world. The number of patients with critical limb ischemia and in risk of amputation is increasing together with increased incidence of cardiovascular diseases. In comparison with comparable population, the prognosis of patients after limb amputation is much worse. In case with no possible revascularisation, stem cell therapy offers a possible option for limb salvage.
Methods: We collected relevant informations from published and accessible studies available on internet database Pubmed in period of 2007−2017. The key words stem cell and critical limb ischemia were used.
Conclusion: Available informations show promising results in the use of stem cells in the treatment of no-option limb ischemia. Multicenter randomized clinical trials and unified recommendations and guidelines are needed to accept this method as available option for treatment. This article is presenting a short rewiev of circumstancies and conditions of this evolving method of treatment.