Development of vascular substitutes for low-flow peripheral bypass grafting – a review
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Keywords

vascular substitutes for low-flow peripheral bypass grafting
testing

Abstract

The development of a low-flow vascular prosthesis is a very topical issue. The authors present a pathway for the development of a prosthesis
with optimal properties based on the idea of mimicking the characteristics of a biological model (saphenous vein graft) and programming
these properties in the model of the prosthetic substitute. The vascular prosthesis presented consists of three layers – a non-absorbable scaffold
representing vascular “media”, and two absorbable collagen layers – pseudointima and pseudoadventitia. The basic methods of physical testing
are presented – the single axis stretch test and inflation-extension test, as well as other procedures that affect the final properties. These include
collagen curing, antithrombotic treatment of the inner layer and the use of sterilization methods. The designed new graft was successfully implanted
in an ovine model.

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