The variable histogenesis and biology of selected bland fibroblastic lesions of the breast – pitfalls in the differential diagnostics and optimal therapeutic approach (three case reports)

Abstract

Presented are three casuistics of seemingly identical breast lesions which even by adopt­ing advanced laboratory techniques may represent diagnostic challenge. Microscopic features of some bland spindle cell lesions of different histogenesis (epithelial or mesenchymal) are misleading and a potential source of unaware errors, which might affect optimal therapeutic strategy. In the setting of three diverse entities (low-grade spindle cell metaplastic carcinoma, desmoid fibromatosis and phyllodes tumor) is doc­umented both demanding diagnostic algorithm and revealing molecular landscape on one side as well as evolving predictive/prognostic parameters on the other one. Close inter­disciplinary cooperation is inevitable for accurate interpretation/understanding of revealed diagnostic facts which is required for adjustment of competent rational and individualized therapy.

Key words

breast – desmoid fibromatosis – low-grade fibromatosis-like metaplastic carcinoma – phyllodes tumor – beta-catenin

doi: 10.48095/ccrvch2024275